Author Topic: Biacore in late stage antibody development  (Read 758 times)

GE-Robert

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Biacore in late stage antibody development
« on: March 30, 2016, 01:23:32 AM »
Biacore™ systems are widely used to support and guide selection of antibody candidates and for characterization of antibodies in late stage development and manufacturing. In the enclosed white paper (WP) “Biacore™ concentration and ligand-binding analyses in late stage development and quality control of biotherapeutics” I review how Biacore supports analysis of critical quality attributes. The WP includes examples of concentration analysis, target-, FcgammaR-, FcRn– and C1q binding. It further illustrates the use of binding mode specific reagents for analysis of higher order structure and introduces sensorgram comparison and CFCA as analytical tools for antibody characterization. It is supported by 51 literature references.

/Robert